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KMID : 0358319960370040371
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Korean Journal of Urology
1996 Volume.37 No. 4 p.371 ~ p.378
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The Study for Isoforms of Nitric Oxide Synthase in the Rat Penis and Major Pelvic Ganglion
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오주현
박광성/김형태/안규윤/류수방
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Abstract
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Immunohistochemical staining was used to evaluate the presence of nitric oxide synthase (NOS) family enzymes in the rat penis and major pelvic ganglion. We used three kinds of antisera which are brain(neuronal), endothelial cell and
macrophage(inducible) enzymes of NOS. Many brain NOS positive neurons were observed in the major pelvic ganglion, especially in the initial portion of the cavernous nerve. In the penile erectile tissue, many delicate, beaded or linear brain
NOS-positive
fibers were observed on the bundle of smooth muscles, adventitia of helicine artery and wall of cavernos space. Brain NOS-positive immunoreactiveity were also seen on the encapsulated nerve ending and adventitia of dorsal vessels of penis.
Endothelial
cell NOS immunoreactivity was exclusively in the urethral epithelium of corpus spongiosum. There was no inducible NOS immunoreactivity in rat penis and major pelvic ganglion. These results suggest that NO related to penile erection in rat was
made
from
brain NOS raher than endothelial cell or inducible NOS.
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